Genetic Markers & Psychosomatic


In 1489, Leonardo da Vinci began to create his iconic series of anatomical drawings for the history of medicine. Over the next twenty-five years, he systematically dissected about thirty human bodies, striving to discover, describe and visualize the construction of the human body.

But how to dissect the function of the neural tissue, the most highly organized and complex system in the human body?

Research such as regeanography, computed tomography, magnetic resonance tomography, pneumoencephalography, ventriculography, cisternography, angiography, thermography, echography, etc. , give topological imaging but not dissection of neurobiology and neurophysiology.




The nervous system in vertebrates and humans according to morphological features is divided into:

  • Central nervous system:
    – Cerebrum
    – Spinal cord
  • Peripheral nervous system


According to functional features are divided into:

  • Somatic Nervous System – Inner the skeletal muscles, thus preserving the posture of the body and ensuring its movement
  • Vegetative Nervous System – regulates the activity of the internal organs and helps maintain the body’s homeokinase.
    – Sympathetic nervous system – pre-ganglion neurons in the spinal cord from the first chest to the second / third lumbar vertebra
    – Parasympathetic nervous system – major brain (III, VII, IX and X) or spinal cord nerves / first to fifth lumbar vertebrae /

The communication in, between and from the nervous system to the underlying parts of the body is accomplished by chemical signaling substances – neurotransmitters.



Homeostasis of physiological processes in the body directly depends, as well as determines neurotransmitter’s  homokinetics.

The construction and function of the human body is encoded in the gene sequences of DNA.

Gene expression is the basis for cellular differentiation, morphogenesis, functionality, which in turn provides the variability and adaptability of each organism.

In this line of thought, dissection of gene expression is required to “dissect” the nervous tissue.

In 2009, Dr. Ronald Dosozer founded Genomind to personalize the approach to investigating patients, especially neuropsychiatry, by a Genecept Assay test involving 18 clinically validated genes (12 pharmacodynamic and 6 pharmacokinetic).


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Presentation Genecept Assay, Genomind by Genomind Representative for Bulgaria –

NM Genomix Company

The genetic test provides information about gene mutation and the indication of appropriate therapy, whether neuropharmacological or alternative.

In 2016 a study was published on the relationship between folate metabolism and autism.

L-Methylfolate supplementation in a child with autism and methyltetrahydrofolate reductase, enzyme gene C677TT allele.


Methyltetrahydrofolate reductase (MTHFR) is an enzyme that converts folic acid from food into an active form. People who have a MTHFR gene mutation can not produce this enzyme and this leads to serious health problems.

MTHFR is related to:

  • Ability to synthesize and absorb bioactive folic acid
  • Absorption of vitamins, minerals, essential fatty acids and amino acids that interact with folic acid
  • The ability to recycle homocysteine ​​to maintain good methylation
  • The generation of important neurotransmitters that affect mental health
  • Synthesis of undamaged DNA and RNA
  • Generating enough white and red blood cells

Key polymorphisms of MTHFR are A1298C and C677T.

C677T is associated with elevated levels of homocysteine ​​and leads to heart disease, Alzheimer’s, Autism.

A1298C affects neurotransmitters and leads to mood swings and addictive tendencies.


One of the 18 test genes in the Genecept Assay Test is MTHFR / A1298C and C677T /.

This makes it possible to detect genetic variations in methylation and to diagnose symptoms correctly, as well as to prepare an appropriate treatment plan for homocysteine ​​and folic acid metabolism.

A complementary approach is the use of L-methyl folate; LMNT / Neurotherapy / Formula for Folic Acid and Vit B12 / LMNT /

NM Genomix is ​​a leader in molecular-genetic research. The team of the company consists of specialists in medical diagnostics, pathology, medical biology and medical biotechnology, which provide competent care for their patients.


Neitropia Clinic and NM Genomix are helping you walk the path from the correct molecular – genetic diagnosis to developing an appropriate treatment plan.



Author Dr. Eliya Kostova